Project Lead, Senior Scientist, Global DMPK&M
Company: Takeda Pharmaceutical
Location: Boston
Posted on: October 23, 2024
Job Description:
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in my employment application is true to the best of my
knowledge.Job DescriptionAre you looking for a patient-focused,
innovation-driven company that will inspire you and empower you to
shine? Join us as Senior Scientist, DMPK Project Lead in our
Cambridge, Massachusetts office. As a member of Global DMPK
organization, you will also have cross-site interactions. At
Takeda, we are transforming the pharmaceutical industry through our
R&D-driven market leadership and being a values-led company. To
do this, we empower our people to realize their potential through
life-changing work. Certified as a Global Top Employer, we offer
stimulating careers, encourage innovation, and strive for
excellence in everything we do. We foster an inclusive,
collaborative workplace, in which our global teams are united by an
unwavering commitment to deliver Better Health and a Brighter
Future to people around the world.As a -DMPK Project Lead for a
diverse range of therapeutic modalities including: cell therapy,
T-cell engager, biologics, oligonucleotides, and small molecules,
you will be empowered to create and communicate a clear DMPK
strategy and champion novel scientific approaches in support of
Drug Discovery and Development for programs in the Takeda
Portfolio.
- Acts as a DMPK functional leader on project teams responsible
for overseeing and managing research activities within the DMPK
department including assigned projects; developing and integrating
the DMPK strategy to progress drug discovery programs.
- Ensures selection and utilization of appropriate in vitro, in
vivo and/or in silico methods and models to address absorption,
distribution, metabolism, excretion (ADME) and pharmacokinetic
(PK)-related issues across several therapeutic areas, including:
Oncology, GI, Neuroscience and all therapeutic modalities, but most
specifically related to biologics, cell therapy, and
oligonucleotide therapies.
- Independently designs studies, collaborates across functions,
implements extensive scientific research projects and plans within
DMPK, and provides leadership to the project teams. Contributes to
multiple projects, acting as senior scientific subject matter
expert, and may be a project team leader and/or provide key
technical knowledge to a project team.ACCOUNTABILITIES -
- Establishes project direction through integrating science, key
technical knowledge, and program objectives
- Provides leadership to enable project teams to make informative
decisions regarding selection and stage up of discovery compounds
for pre-clinical development in Oncology, GI and Neuroscience
areas
- Actively contributes to the evaluation of potential drug
candidates for in-licensing
- Contributes to the preparation/editing/review of documents for
regulatory submission (i.e., study reports, IB's, IND's)
- Independently and/or collaboratively conducts PK and PK/PD
analyses during late-stage lead optimization through early
pre-clinical development and collaborates in PK/PD and efficacy
study design to support clinical dose setting
- Provides strategic and hands-on leadership relating to PK and
ADME issues for diverse modalities including but not limited to T
cell engagers, cell therapies, biologics and oligonucleotides
- Develops and mentors junior DMPK team membersDIMENSIONS AND
ASPECTS Technical/Functional (Line) Expertise
- Demonstrates well-developed knowledge of other
disciplines/departments and how they function together
- Demonstrates exceptional project management skills and/or broad
recognition forin-depth expertise in a scientific
disciplineLeadership
- Designs and directs research strategy and activities to meet
program objectives
- Provide leadership, timelines, and contingency plans - - - - -
- - - - - - -Decision-making and Autonomy
- Scientific driver for research strategy that impacts group
internally and outside area of function. Independently manages
workload and expectations
- Scientifically independentInteraction
- Initiates and leads external interactions and
collaborations
- Frequent contact with internal and external personnel at
various management levels
- Collaborates with other departments and disciplines, acting as
scientific authority withindiscipline
- Serves as senior company/ project representative at external
conferences or business meetingsInnovation
- Determines methods on new assignments; makes strategic
recommendations on projects; greater demonstrated independence; may
manage junior staffEDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS: -
- PhD degree in a scientific discipline with 3+ years experience
, or MS with 9+ years experience, or BS with 11+ years
experience
- Deep expertise in DMPK of cell therapies, biologics, small
molecules, or oligonucleotides, - knowledge in PK/PD/E modeling and
application to clinical dose setting and predicting human
efficacious dose.
- Experience in serving on project teams in early discovery
through marketing is critical. Managing the ADME and PK screening
paradigm in early lead optimization, as well as early phase 1
design and human PK predictions are minimum requirements.
- Clear track record of accomplishments (e.g. publications,
patents, presentations), including evidence of leadership in
managing DMPK core activities and taking one or more internally
discovered compounds into preclinical and/or clinical
development.
- Recognized in the field of DMPK by both the pharmaceutical
industry and the academic community.
- Excellent oral and written communication skills and an ability
to interact and conduct strategic planning with colleagues in other
scientific disciplines.
- In-depth knowledge of the overall drug discovery process and
demonstrated ability to successfully direct efforts on multiple
projects simultaneously.
- Experience in PBPK modeling is highly desired
- Software proficiency in Phoenix and/or Watson, GastroPlus and
Simcyp is highly desired
- Experience in compiling and writing IND modules is
desiredLocation: Cambridge, MATakeda Compensation and Benefits
SummaryWe understand compensation is an important factor as you
consider the next step in your career. We are committed to
equitable pay for all employees, and we strive to be more
transparent with our pay practices. -For Location:Boston, MAU.S.
Base Salary Range:$133,000.00 - $209,000.00The estimated salary
range reflects an anticipated range for this position. The actual
base salary offered may depend on a variety of factors, including
the qualifications of the individual applicant for the position,
years of relevant experience, specific and unique skills, level of
education attained, certifications or other professional licenses
held, and the location in which the applicant lives and/or from
which they will be performing the job.---The actual base salary
offered will be in accordance with state or local minimum wage
requirements for the job location. -U.S. based employees may be
eligible for short-term and/ or long-term incentives. U.S. based
employees may be eligible to participate in medical, dental, vision
insurance, a 401(k) plan and company match, short-term and
long-term disability coverage, basic life insurance, a tuition
reimbursement program, paid volunteer time off, company holidays,
and well-being benefits, among others. U.S. based employees are
also eligible to receive, per calendar year, up to 80 hours of sick
time, and new hires are eligible to accrue up to 120 hours of paid
vacation. -EEO StatementTakeda is proud in its commitment to
creating a diverse workforce and providing equal employment
opportunities to all employees and applicants for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, gender expression, parental status, national
origin, age, disability, citizenship status, genetic information or
characteristics, marital status, status as a Vietnam era veteran,
special disabled veteran, or other protected veteran in accordance
with applicable federal, state and local laws, and any other
characteristic protected by law.LocationsBoston, MAWorker
TypeEmployeeWorker Sub-TypeRegularTime TypeFull time
Keywords: Takeda Pharmaceutical, Framingham , Project Lead, Senior Scientist, Global DMPK&M, Other , Boston, Massachusetts
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